This paper is a part of a Master’s thesis, which is a group work. I have attached the draft of the whole work (PAP Master Thesis.pdf) for a clearer picture. Other texts attached (case studies and others) may be used additionally, they are the result of SLR.I need 12 pages for the individual part, which answers the research question: What differences between RWE and randomized controlled trials (RCTs) are highlighted in HTA guidelines, and how do these differences impact the assessment of effectiveness and safety?The references should be made in Chicago (author-date) style.They check for AI so please, the text should be/sound not like chatGPT. A lot of useful info such as HTA guidelines used and concepts of RWE, HTA are already in there.