Create a summary report with reference library about factors known to cause “sticking”/adhesiveness in API. Assemble documentation/understanding of which physical and chemical characteristics can cause adhesiveness/cohesiveness in bulk API material, causing the material to: adhere to itself, adhere to surfaces, impact the flow of solids during handling and flow through equipment. Capture different methods of measurement and what can be learned from each.
Thesis are good for format
Label sections as such::
Contents
I. Introduction, Background
A. Tableting process
1) Compression
2) Wet Granulation
3)Dry Granulation
C. Common Problems associated with sticking
1.Tablet sticking and picking
a) factors contributing to sticking
1) tablet manufacturing factors contributing to tablet sticking
2) environmental factors contributing to tablet sticking
Techniques to measure/predict tablet sticking
1)FT4/ powder rheology
2) Atomic force microscopy
3)Optical microscopy
etc
Must include the following in the paper:
Surfaces
Quantitative number
sticking’s of molecule
Friction
Bulk API
Bulk power
API particle habit
Ethyl and isopropyl acetate (sticky, gummy precipitate)
Surface area
Surface energy
Lattice shape
Flodex
Hydrophobic
Dipole
All 15 sources/references must be used which I supplied.
