Personality disorders are often seen comorbid with other psychiatric illnesses. Some have a much higher prevalence than others and often complicate the clinical picture. Of all the personality disorders (PD), borderline PD, histrionic PD, antisocial PD, and narcissistic PD are frequently seen and demand the attention of the provider. Discuss the limitations of treatment for borderline and histrionic PD and what can be done from a psychopharmacological perspective. Discuss the limitations of treatment for antisocial and narcissistic PD and what can be done from a psychopharmacological perspective.