and Treatment

Introduction Alpha1-antitrypsin (A1AT) deficiency is a rare genetic disorder primarily associated with an increased susceptibility to chronic obstructive pulmonary disorder (COPD), non-alcoholic cirrhosis of the liver, and panniculitis. The disorder results from defective alleles of the SERPINA1 gene, which codes for the A1AT protein. The normal allele, denoted as M, acts as a regulator of … Read more