please find attached documents to answer the following questions
please use the attached document for reference style
please label the questions 1, 2,3 etc
Question 3
What is the difference in the age at initial presentation between alpha-thalassemia and beta-thalassemia, and why is there a difference?
The hemoglobinopathies are normocytic anemias except for HbE disease and trait that presents with a microcytic, hypochromic RBC morphology. Explain the reason for this finding?
Question 4
When a patient has sickle cell anemia and also has alpha thalassemia or iron deficiency anemia, the symptoms are less severe. Explain the reason for that. Why does the opposite happen when sickle cell is combined with a beta thalassemia gene?
Question 5
What are the risks and benefits of chronic transfusion in a sickle cell anemia and beta thalassemia major? How can the risks be minimized? Is there a transfusion policy related to this at your institution?
Question 6
In what ways do environmental and physiological conditions, such as pH and oxygen levels, influence the polymerization of sickle hemoglobin (Hb S) and the onset of sickle cell crises?
Question 7
How does the presence of fetal hemoglobin (Hb F) impact the clinical severity of sickle cell disease, and why might this be a therapeutic target?
Question 8
How does iron overload occur in thalassemia patients, especially those with transfusion dependence, and what are the current management strategies to mitigate its effects?
Question 9
What are the implications of splenomegaly and splenectomy in the management of thalassemia, and how do they impact disease progression?
