What are the main differences between a lab-based proposal/project and a lit review proposal/project?

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Look at the example proposals posted (https://www.niaid.nih.gov/grants-contracts/sample-applications) and (attachment 1: Project proposal pdf), and answer the following questions:
1.) What are the main similarities between a lab-based proposal/project and a lit review proposal/project?
2.) What are the main differences between a lab-based proposal/project and a lit review proposal/project?
3.) What will a lab-based project have that a lit review project will not?

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