Review the difference between types of evidence available in clinical practice. Refer to the evidence-based levels chart as you discuss the evidence related to your clinical question. PICOT question: In persons aged 25-65 years (P), what is the importance of stop smoking interventions (I) compared to the use of nicotine cigarettes (C) on the health of these individuals (O) over one year (T)? See the evidence-based pyramid chart in the textbook (the chart is attached here) 3 (three) credible sources of support (within 5 years) are required.