After reviewing the major aspects of muscle contraction and recruitment, it’s time to turn our attention into the cellular pathways involved in repair and growth, and take a special look at the important and often under-rated structure known as the sarcoplasmic reticulum.
Prompt: Choose one of the following
1) Muscle Regeneration
Soreness is caused by inflammation in the area of damaged muscle – and we are most likely to damage muscle during eccentric contractions (when muscles are lengthening under tension) such as when we are decelerating weight or running downhill. Fortunately, this process initiates a regeneration phase. In this video:
– Describe the phases of muscle regeneration.
– Review the players involved (i.e. satellite cells) and the signaling pathways that initiate muscle recovery.
– Highlight the role of one of the players such as AMPK, stem cells, and macrophages in the process of initiating recovery.
2) The Sarcoplasmic Reticulum
Sure, it stores a lot of calcium and releases this calcium to enable muscle contraction. But in this video, you’ll cover a few more details.
– Describe the location of the sarcoplasmic reticulum and the process of converting an action potential to a release of calcium by the SR
– Explain the role of calsequestrin proteins inside sarcoplasmic reticulum
– Review how calcium returns back into the SR via calcium channels.
Resources
– Calcium Channels – Ninja Nerd, Minute 9
– Search for review papers or topics related to the sarcoplasmic reticulum on library.tulane.search.edu, or PubMed
3) Factors in Cell Hypertrophy
In this video, you’ll feature a few of the underlying mechanisms behind muscle cell hypertrophy #gains or atrophy (#loss?).
After reading the following review on The Mechanisms of Muscle Hypertrophy and Their Application to Resistance Training, summarize one of the following sections by finding and creating visuals and/or analogies to explain the content:
1) Satellite Cells and Muscle Hypertrophy + Myogenic Pathways
2) Hormones and Cytokines
3) Cell Swelling and Hypoxia
4) Initiation of Exercise-Induced Muscle Cell Hypertrophy
You may opt keep on reading to gain insight into how this basic science acts as a foundation for Exercise Prescription.
Instructions:
1. Research your topic using the resources provided as well as valid external resources such as research papers.
2. Design your 5 minute video. This may be a slide presentation, a recording of you drawing out your pathway on a whiteboard, an explainer using complete anatomy, or a combination of the three.
3. Record yourself. To do so, you may use a screen capture application such as Snipit or Screenshot (on Mac). As you do, make sure the produced file is a video file (i.e. .mp4)
4. Publish to a hosting site. Videos are to be published as Unlisted, not Private or Public.
5. Post your video link. The link should follow a 1-line title of your chosen topic. If outside sources such as research papers or textbooks were used, please include citations in APA format in your submission below the link to your video. Below is an example of a submission using a topic from Module 7 topic. You will not be able to view your classmates work until your work is submitted.
Cardiac Action Potentials and the Autonomic Nervous System
YouTube.com/demo
Faber, G. M., & Rudy, Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal, 78(5), 2392–2404. https://doi.org/10.1016/S0006-3495(00)76783-X
