Why are 4 H+ needed for every ATP synthesized and exported by mitochondria, even though only 3 H+ need to be translocated by the ATP Synthase Complex to synthesize one ATP?

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All of the questions for the week are in a single Discussion post – you need to provide a short a succinct answer to each of my questions. Be brief and accurate using ~3-4 sentences for each answer, although longer is fine if needed. Number each of your answers to match my numbered questions; week 1 question 1 is 1.1, week 1 question 2 is 1.2, etc. You will not receive credit if you copy the answers directly from the textbook or from another student, including a shared internet resource – write the answers in your own words. Step 2: Choose one of my questions to write a follow-up question to and include your question at the bottom of this same post “My follow-up question to RLM question 1.1 is:…”

The ATPase Synthase Complex

Q12.1: Why are 4 H+ needed for every ATP synthesized and exported by mitochondria, even though only 3 H+ need to be translocated by the ATP Synthase Complex to synthesize one ATP?

Mitochondrial Shuttle Systems

Q12.2: Explain why NADH synthesized in the cytosol of liver cells and used for mitochondrial energy conversion generates 2.5 ATP per NADH, whereas NADH synthesize in muscle cell cytosol only generates 1.5 ATP per NADH?

Regulation of Oxidative Phosphorylation

Q12.3: What is unusual about the genetically-inherited mitochondrial disease LHON as compared to the genetically-inherited disease sickle cell anemia?

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