Explain the limitation of In silico prediction tools for genetic variant interptration and classfcation.

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Explain the limitation of In silico prediction tools for genetic variant interptration and classfcation.Please see the attached outline. I also will add a useful referances to be used .Referances :https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1353-5#:~:text=The%20ACMG%2FAMP%20guideline%20for%20use%20of%20in%20silico,should%20not%20be%20used%20in%20classifying%20a%20variant.%E2%80%9Dhttps://pubmed.ncbi.nlm.nih.gov/26377032/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870501/

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