Health officials have identified an emergent infectious, respiratory disease that is spreading rapidly from a single geographic point of origin. You are part of an advance team to develop a vaccine as rapidly as possible.
1. The first critical set of information you need to begin your vaccine design is the genome sequence of the pathogen. Describe the technical approach you will use to obtain this information? (10 pts)
2. What do you expect the vaccine to do when introduced to the host? (3 pts)
3. What component of the pathogen will you use to constitute the vaccine? Why? (5 pts)
4. What vaccine strategy will you use (use drawings as necessary)?
a. Detail the approach you will take to get expression of your viral antigen. (10 pts)
b. How will you ensure that your vaccine remains viable during distribution to remote populations? (5pts)
c. How will you address the emergence of viral variants to which your vaccine has reduced efficacy? (5 pts)
5. Cite your references (any format is acceptable). (2 pts)
