What was the original purpose of the The 1946 National Birth Cohort?

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Part I

This part is based on the The 1946 National Birth Cohort (MRC National Survey of Health and Development).

Science: From Cradle to Grave (Links to an external site.)Links to an external site. (Links to an external site.) This is a 30 minute podcast that goes into detail about the 1946 British National Birth Cohort. Please make sure that you give yourself some time to listen.

Also review the following publication: Michael Wadsworth, Diana Kuh, Marcus Richards, Rebecca Hardy; Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development), International Journal of Epidemiology, Volume 35, Issue 1, 1 February 2006, Pages 49–54, https://doi.org/10.1093/ije/dyi201 (Links to an external site.)Links to an external site. (Links to an external site.)

What was the original purpose of the The 1946 National Birth Cohort?

Is this an exposure-based cohort or population-based cohort? How do you know?

Who is in the sample? How many?

How often have they been followed?

What are 2 interesting (to you) exposures/outcomes that are being collected in this cohort? At what point were they collected?

Define what is meant by “attrition”. How does this affect a cohort study?

7. Name one strength and one weakness of a cohort study, and show how those are demonstrated in this study.

Part II Cohort study measures of association.

In a study examining the association between exposure to silica dust and shortness of breath, 750 workers exposed to silica dust (exposed) were followed for 5 years. They were compared to 3000 workers without silica exposure. By the end of the study, 150 of the silica exposed workers and 300 of the non-exposed workers were diagnosed with shortness of breath.

8. Show the 2 X 2 table, with appropriate totals, and compute the incidence for those with and without exposure, along with the relative risk (risk ratio) for this cohort study. Show your work and the appropriate units. What did the results show?

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